ea0049oc14.3 | Thyroid Cancer | ECE2017
Melo Miguel
, Gaspar da Rocha Adriana
, Batista Rui
, Vinagre Joao
, Joao Martins Maria
, Costa Gracinda
, Ribeiro Cristina
, Carrilho Francisco
, Leite Valeriano
, Lobo Claudia
, Manuel Cameselle-Teijeiro Jose
, Sobrinho-Simoes Manuel
, Soares Paula
Context: Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with the primary tumor genotype.Objectives: To evaluate the frequency of TERT promoter (TERTp), BRAF and NRAS mutations in metastatic thyroid carcinomas, analyzing primary thyroid tumors, lymph node metastases (LNM) and distant metastases.Material and Methods: Mutation analysis was performed in 437 tissue samples from 204...